This is the thoroughly updated and revised edition of the book, which has been redesigned and recast as per the latest CBME Guidelines | Competency Based Undergraduate Curriculum for the Indian Medical Graduate. The chapters in the book have been modified from the traditional organism-based teaching to system-based teaching. The uniqueness of the book is in the clinical case-based exercises and student activities after each practical to assess their learning and practical knowledge. The text is presented in a simple and lucid manner. The text is illustrated with eight colour plates containing 50 figures, computer-drawn figures and photomicrographs. These make the book colourful and the readers can have a better understanding. It will continue to serve as an ideal practical workbook for all MBBS and BDS students